Buffalo Bills running back Fred Jackson is out at least three weeks and wide receiver David Nelson is done for the rest of the 2012 season.
Both players were injured in Sunday's loss to the New York Jets and Bills coach Chan Gailey updated their status on Monday.
An MRI exam on Jackson's right knee was inconclusive, while Nelson reportedly tore the ACL in his right knee.
Jackson went on injured reserve last November with a broken right leg. He signed a two-year extension with Buffalo in the offseason.
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