Jacksonville Jaguars running back Maurice Jones-Drew left early in the first quarter of Sunday's game against the Oakland Raiders.
Jones-Drew appeared to injure his left foot on his first carry and was later on the sideline with tape on the ankle.
His return to the game is questionable.
Coming into the game, the 2011 NFL rushing champion had 408 yards and one touchdown on 84 carries this season. Jones-Drew has added 14 catches for 86 yards and a score.