American Airlines will lay off 22 workers at Sea-Tac Airport beginning Sept. 5 as part of its nationwide staff reduction.

That news came Tuesday in a warning notice filed with the state Employment Security Department. Nationwide, American plans to eliminate 6,500 employees, or about 8 percent of its work force.

Some employees may leave the company voluntarily with a severance package designed to bridge the gap between full-time employment and retirement, the company said.

American and most other major airlines plan to cut back flying beginning this fall to allow fuel-guzzling older aircraft to be grounded and to cull unprofitable flights from their schedules.

American hasn’t yet announced specific flight reductions at Sea-Tac, but it’s expected that the airline will consolidate some of the multiple flights it schedules between Sea-Tac and its hubs in Chicago and Dallas.