Tailback Chris Polk's career-long 53-yard touchdown run less than five minutes into the final quarter put the clamps on the Huskies' first victory this season.
Polk went around the left end. Fullback Austin Sylvester sealed off the edge, and the sophomore broke free with nobody in sight except teammate Devin Aguilar for the long score, and 34-13 lead with 10:14 to go.
The UW scored three unanswered touchdowns in the second half, capped by Polk's first score this season. Jermaine Kearse had a pair of touchdown catches in the third quarter to break open a tight game.
Polk's fumble on a third-and-short run – the UW's first turnover this season – set up the Orange's only second-half touchdown. Ryan Nassib hit Alec Lemon on a 20-yard pass in the right corner of the end zone with 7:13 to go.
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Jake Locker tossed his fourth touchdown pass of the game after the Syracuse score, this time hitting Aguilar on a slant patters along the left seam. The junior made a superb snatch in front of safety Max Suter at the 6:33 mark.
Kearse finished with a career-high nine receptions for 179 yards and three touchdowns.
The 41 points were the second-most scored since coach Steve Sarkisian took over in 2009. The UW beat Idaho, 42-23, in the second game, and California, 42-10, in the finale. Both games were at Husky Stadium.