Can the run offense get going to the satisfaction of Mike Holmgren, particularly with Shaun Alexander still affected by a cracked bone in his wrist? The return of Mo Morris may help that.
Can the run defense repeat its performance from a week ago and stop Frank Gore, especially against a much-bigger offensive line that dominated the Seahawks the past two games?
How will Darrell Jackson fare against his former teammates? He is the leading Niners receiver with 11 receptions. But you know the Hawks will be focused on shutting him down.
If the defensive line is focused on stopping Gore, will it be able to get pressure on Alex Smith as well?
Will Mike Holmgren loosen up the conservative play-calling to take advantage of Matt Hasselbeck's hot start?
Which wide receiver will emerge this week as the replacement for Jackson? It has been a different one each week.
Will Marcus Pollard re-establish a presence in the offense? He had five receptions the first week, one since.
How will the loss of TE Vernon Davis affect the Niners?
Just for the record, I disagree with Brock Huard and think this is going to be a blowout Seahawks victory. I think they understand the affect of losing both those games last year, and I think Holmgren has gotten that ingrained in the players this week. I also get the sense that the offense is tired of playing around and wants to put together a complete game to make a statement, and this is where they do it. I think they realize if they go up early, it puts the pressure on Smith to produce and that is not San Francisco's strength. I also think Holmgren has made them realize the importance of the game in terms of winning the division. Plus, I think San Francisco has some issues right now that will play an affect. I'm saying 30-10.